Rex, if economy is the absolute priority, headers still win out through lower total back pressure, although in practice the difference may be more theoretical than practical over what you are proposing.
Biggest gains will come from a much higher compression ratio and some really creative valve timing.
I suggest you research "Atkinson Cycle" and "Miller cycle" engines.
These usually always run a supercharger for best results, but you can do something very similar with a normally aspirated engine.
The trick is to close the inlet valve very late, when the piston is a long way up the bore.
This reduces the dynamic compression ratio because compression only begins after the inlet valve has completely closed.
This enables you to run a crazy high compression ratio with a very small combustion chamber without exceeding the temperatures and pressures that could reach the detonation threshold.
Once it fires, you can get a very high expansion ratio, especially if you keep the exhaust valve opening very late.
This won't get you any more power, but it can sure will help the BSFC and thermal efficiency if that is your main goal.
A much larger exhaust valve can also help reduce exhaust pumping losses which also helps.